33 research outputs found
Quality of life depends on the drinking pattern in alcohol-dependent patients.
AIMS: In patients with alcohol dependence, health-related quality of life (QOL) is reduced compared with that of a normal healthy population. The objective of the current analysis was to describe the evolution of health-related QOL in adults with alcohol dependence during a 24-month period after initial assessment for alcohol-related treatment in a routine practice setting, and its relation to drinking pattern which was evaluated across clusters based on the predominant pattern of alcohol use, set against the influence of baseline variables
METHODS: The Medical Outcomes Study 36-Item Short-Form Survey (MOS-SF-36) was used to measure QOL at baseline and quarterly for 2 years among participants in CONTROL, a prospective observational study of patients initiating treatment for alcohol dependence. The sample consisted of 160 adults with alcohol dependence (65.6% males) with a mean (SD) age of 45.6 (12.0) years. Alcohol use data were collected using TimeLine Follow-Back. Based on the participant's reported alcohol use, three clusters were identified: 52 (32.5%) mostly abstainers, 64 (40.0%) mostly moderate drinkers and 44 (27.5%) mostly heavy drinkers. Mixed-effect linear regression analysis was used to identify factors that were potentially associated with the mental and physical summary MOS-SF-36 scores at each time point.
RESULTS: The mean (SD) MOS-SF-36 mental component summary score (range 0-100, norm 50) was 35.7 (13.6) at baseline [mostly abstainers: 40.4 (14.6); mostly moderate drinkers 35.6 (12.4); mostly heavy drinkers 30.1 (12.1)]. The score improved to 43.1 (13.4) at 3 months [mostly abstainers: 47.4 (12.3); mostly moderate drinkers 44.2 (12.7); mostly heavy drinkers 35.1 (12.9)], to 47.3 (11.4) at 12 months [mostly abstainers: 51.7 (9.7); mostly moderate drinkers 44.8 (11.9); mostly heavy drinkers 44.1 (11.3)], and to 46.6 (11.1) at 24 months [mostly abstainers: 49.2 (11.6); mostly moderate drinkers 45.7 (11.9); mostly heavy drinkers 43.7 (8.8)]. Mixed-effect linear regression multivariate analyses indicated that there was a significant association between a lower 2-year follow-up MOS-SF-36 mental score and being a mostly heavy drinker (-6.97, P < 0.001) or mostly moderate drinker (-3.34 points, P = 0.018) [compared to mostly abstainers], being female (-3.73, P = 0.004), and having a Beck Inventory scale score ≥8 (-6.54, P < 0.001), at baseline. The mean (SD) MOS-SF-36 physical component summary score was 48.8 (10.6) at baseline, remained stable over the follow-up and did not differ across the three clusters. Mixed-effect linear regression univariate analyses found that the average 2-year follow-up MOS-SF-36 physical score was increased (compared with mostly abstainers) in mostly heavy drinkers (+4.44, P = 0.007); no other variables tested influenced the MOS-SF-36 physical score.
CONCLUSION: Among individuals with alcohol dependence, a rapid improvement was seen in the mental dimension of QOL following treatment initiation, which was maintained during 24 months. Improvement was associated with the pattern of alcohol use, becoming close to the general population norm in patients classified as mostly abstainers, improving substantially in mostly moderate drinkers and improving only slightly in mostly heavy drinkers. The physical dimension of QOL was generally in the normal range but was not associated with drinking patterns
Nonlinear force-free and potential field models of active-region and global coronal fields during the Whole Heliospheric Interval
Between 2008/3/24 and 2008/4/2, the three active regions NOAA active regions
10987, 10988 and 10989 were observed daily by the Synoptic Optical Long-term
Investigations of the Sun (SOLIS) Vector Spectro-Magnetograph (VSM) while they
traversed the solar disk. We use these measurements and the nonlinear
force-free magnetic field code XTRAPOL to reconstruct the coronal magnetic
field for each active region and compare model field lines with images from the
Solar Terrestrial RElations Observatory (STEREO) and Hinode X-ray Telescope
(XRT) telescopes. Synoptic maps made from continuous, round-the-clock Global
Oscillations Network Group (GONG) magnetograms provide information on the
global photospheric field and potential-field source-surface models based on
these maps describe the global coronal field during the Whole Heliospheric
Interval (WHI) and its neighboring rotations. Features of the modeled global
field, such as the coronal holes and streamer belt locations, are discussed in
comparison with extreme ultra-violet and coronagraph observations from STEREO.
The global field is found to be far from a minimum, dipolar state. From the
nonlinear models we compute physical quantities for the active regions such as
the photospheric magnetic and electric current fluxes, the free magnetic energy
and the relative helicity for each region each day where observations permit.
The interconnectivity of the three regions is addressed in the context of the
potential-field source-surface model. Using local and global quantities derived
from the models, we briefly discuss the different observed activity levels of
the regions.Comment: Accepted for publication in the Solar Physics Whole Heliospheric
Interval (WHI) topical issue. We had difficulty squeezing this paper into
arXiv's 15 Mb limit. The full paper is available here
ftp://gong2.nso.edu/dsds_user/petrie/PetrieCanouAmari.pd
How to optimize nonlinear force-free coronal magnetic field extrapolations from SDO/HMI vector magnetograms?
The SDO/HMI instruments provide photospheric vector magnetograms with a high
spatial and temporal resolution. Our intention is to model the coronal magnetic
field above active regions with the help of a nonlinear force-free
extrapolation code. Our code is based on an optimization principle and has been
tested extensively with semi-analytic and numeric equilibria and been applied
before to vector magnetograms from Hinode and ground based observations.
Recently we implemented a new version which takes measurement errors in
photospheric vector magnetograms into account. Photospheric field measurements
are often due to measurement errors and finite nonmagnetic forces inconsistent
as a boundary for a force-free field in the corona. In order to deal with these
uncertainties, we developed two improvements: 1.) Preprocessing of the surface
measurements in order to make them compatible with a force-free field 2.) The
new code keeps a balance between the force-free constraint and deviation from
the photospheric field measurements. Both methods contain free parameters,
which have to be optimized for use with data from SDO/HMI. Within this work we
describe the corresponding analysis method and evaluate the force-free
equilibria by means of how well force-freeness and solenoidal conditions are
fulfilled, the angle between magnetic field and electric current and by
comparing projections of magnetic field lines with coronal images from SDO/AIA.
We also compute the available free magnetic energy and discuss the potential
influence of control parameters.Comment: 17 Pages, 6 Figures, Sol. Phys., accepte
The free energy of NOAA active region AR 11029
The NOAA active region AR 11029 was a small but highly active sunspot region
which produced 73 GOES soft X-ray flares. The flares appear to show a departure
from the well known power-law frequency-size distribution. Specifically, too
few GOES C-class and no M-class flares were observed by comparison with a
power-law distribution (Wheatland in Astrophys. J. 710, 1324, 2010). This was
conjectured to be due to the region having insufficient magnetic energy to
power large events. We construct nonlinear force-free extrapolations of the
coronal magnetic field of active region AR 11029 using data taken on 24 October
by the SOLIS Vector-SpectroMagnetograph (SOLIS/VSM), and data taken on 27
October by the Hinode Solar Optical Telescope SpectroPolarimeter (Hinode/SP).
Force-free modeling with photospheric magnetogram data encounters problems
because the magnetogram data are inconsistent with a force-free model, and we
employ a recently developed `self-consistency' procedure which addresses this
and accommodates uncertainties in the boundary data (Wheatland and Regnier in
Astrophys. J. 700, L88, 2009). We calculate the total energy and free energy of
the self-consistent solution and find that the free energy was 4x10^29 erg on
24 October, and 7x10^31 erg on 27 October. An order of magnitude scaling
between RHESSI non-thermal energy and GOES peak X-ray flux is established from
a sample of flares from the literature and is used to estimate flare energies
from observed GOES peak X-ray flux. Based on the scaling, we conclude that the
estimated free energy of AR 11029 on 27 October when the flaring rate peaked is
sufficient to power M-class or X-class flares, and hence the modeling does not
appear to support the hypothesis that the absence of large flares is due to the
region having limited energy.Comment: Accepted for publication in Solar Physic
PND43 IMPACT OF MEMANTINE TREATMENT INITIATION ON PSYCHOTROPICS USE: ANALYSES WITH THE RAMQ DATABASE
Variational equations of hydromagnetic equilibria
Available from CEN Saclay, Service de Documentation, 91191 Gif-sur-Yvette Cedex (France) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc